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Simvastatin News: Lipitor safer for heart vs. generic? Pfizer's cholesterol-lowering drug Lipitor significantly cut the risk of heart attacks and stroke compared with simvastatin, says a U.S. analysis. Drug Combo May Benefit Heart-Disease Patients Nondiabetics with heart disease who take the diabetes drug pioglitazone along with the cholesterol-lowering drug simvastatin appear to have a reduction in insulin resistance. Dr. Reddy's gets FDA nod for simvastatin Indian drug maker Dr. Reddy's Laboratories Ltd. has received final approval from the U.S. Food and Drug Administration for cholesterol-lowering simvastatin tablets.